становится активным "сам по себе"

English translation: becomes constitutively active

17:19 May 9, 2004
Russian to English translations [PRO]
Science - Biology (-tech,-chem,micro-)
Russian term or phrase: становится активным "сам по себе"
при мутациях или делециях в трансмембранном сегменте в ... рецептора становится активным "сам по себе", не требуя лигандов для активации
rooky
English translation:becomes constitutively active
Explanation:
Похоже, речь идет не о "самоактивации" (хотя такое тоже встречается - см. автофосфорилирование), а о том, что "изуродованный" рецептор активен постоянно, сам по себе, не требуя никакой активации, i.e. "constitutively".
Selected response from:

nuclear
Local time: 05:20
Grading comment
Именно так. Спасибо
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +3self-activates
Irene N
5 +1becomes constitutively active
nuclear
4 +1activate themselves
GaryG
3in itself; on its own accord
Kirill Semenov
3autoactivates
Giacomo Camaiora (X)
3active per se
Elena Ivaniushina


  

Answers


4 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
activate themselves


Explanation:
I'm not sure if "self-activate" is a medical or biological term

--------------------------------------------------
Note added at 2004-05-09 17:25:32 (GMT)
--------------------------------------------------

It seems that \"self-activate\" IS an (?the?) accepted term: www.biochem.arizona.edu/gillies/bc801/lecture10.pdf

GaryG
Local time: 22:20
Native speaker of: Native in EnglishEnglish
PRO pts in category: 4

Peer comments on this answer (and responses from the answerer)
agree  Natalie: ...presenilins may, in fact, be -secretases—self-activated enzymes that... http://pubs.acs.org/hotartcl/cenear/991206/7749health.html
1 hr
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5 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
становится активным
in itself; on its own accord


Explanation:
on its own accord

--------------------------------------------------
Note added at 8 mins (2004-05-09 17:27:11 GMT)
--------------------------------------------------

becomes active om its own accord (what a shame ;))

Kirill Semenov
Ukraine
Local time: 05:20
Native speaker of: Native in RussianRussian
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13 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
становится активным
self-activates


Explanation:
The enzyme self-activates at acidic pH by removing the prosegment, leaving the mature enzyme in the proper conformation.



    Reference: http://web.clas.ufl.edu/CLAS/jur/0902/henrypaper.html
Irene N
United States
Local time: 21:20
Native speaker of: Native in RussianRussian

Peer comments on this answer (and responses from the answerer)
agree  Natalie
53 mins
  -> Спасибо!

agree  mk_lab
59 mins
  -> Спасибо!

agree  David Mitchell
6 hrs

neutral  nuclear: I suspect it is not "self-activation" in this case - self activation may require ligands or regulatory molecules. Sometimes genetically modified enzymes and receptors become "constitutively active" and this appars to be the case here
18 hrs
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23 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
становится активным
autoactivates


Explanation:
Джакомо



Giacomo Camaiora (X)
Italy
Local time: 04:20
Native speaker of: Native in ItalianItalian
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5 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
становится активным "сам по себе"
active per se


Explanation:
Думаю, что авторы мысленно имели в виду это выражение.

Elena Ivaniushina
Russian Federation
Local time: 05:20
Specializes in field
Native speaker of: Russian
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18 hrs   confidence: Answerer confidence 5/5 peer agreement (net): +1
становится активным "сам по себе"
becomes constitutively active


Explanation:
Похоже, речь идет не о "самоактивации" (хотя такое тоже встречается - см. автофосфорилирование), а о том, что "изуродованный" рецептор активен постоянно, сам по себе, не требуя никакой активации, i.e. "constitutively".

nuclear
Local time: 05:20
Works in field
Native speaker of: Native in RussianRussian
PRO pts in category: 4
Grading comment
Именно так. Спасибо

Peer comments on this answer (and responses from the answerer)
agree  Martinique: Ну очень похоже на правду...
1 day 10 hrs
  -> Thanks :)
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