English to Spanish Medical Medical: Pharmaceuticals

Estoy traduciendo un artículo titulado "Subcutaneous Bortezomib In Multiple Myeloma". En la introducción dice:

"Defective intracellular proteins **are targeted for** proteasomal degradation via ubiquitination, with the ubiquitin-proteasome pathway also being responsible for degrading the majority of regulatory eukaryotic proteins, including those that mediate apoptosis and cell cycle progression (such as B-cell lymphoma-2, caspases and cyclins) and activate nuclear factor (NF)-ĸB.

By inhibiting the 26S proteasome, bortezomib prevents its targeted proteolysis, thereby affecting multiple intracellular signalling cascades, including NF-ĸB (which promotes multiple myeloma cell growth, survival and drug resistance when activated in cellular stress), c-Jun N-terminal kinase (which promotes cell death in response to stress and elevated levels of misfolded proteins), caveolin-1 (which is involved in cell migration and motility), the cyclin-dependent kinase inhibitors p21 and p27, the proapoptotic proteins Bax and Bid and the tumour suppressor p53, and leading ultimately to cell death. As a result of its inhibition of NF-ĸB activation, bortezomib reduces the binding of multiple myeloma cells to bone marrow stromal cells "

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