10 mg step dose
Russian translation: целевая доза, достигаемая пошаговым увеличением, 10 мг
| 00:45 Dec 26, 2023 |
| English to Russian translations [PRO] Medical - Medical: Pharmaceuticals / investigator brochure | |||||||
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|  Selected response from: Edgar Hermann Local time: 07:33 | ||||||
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| 3 +1 | целевая доза, достигаемая пошаговым увеличением, 10 мг |
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Answers
9 hrs confidence: 
peer agreement (net): +1
peer agreement (net): +1целевая доза, достигаемая пошаговым увеличением, 10 мг Explanation: группы с пошаговым увеличением дозы до целевого значения 10 и 100 мг |
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Reference comments
11 hrs |
| Reference Reference information: https://rosoncoweb.ru/news/oncology/2023/12/06/ -------------------------------------------------- Note added at 11 hrs (2023-12-26 12:11:38 GMT) -------------------------------------------------- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980545/ Using the body’s immune system to recognize and kill cancer cells is an enticing prospect within oncology, showing great promise with several different therapeutic approaches. Among these are bispecific T-cell engagers (TCE), which can overcome some of the limitations of the body’s natural immune system by recruiting T cells to the tumor site and stimulating their activation and proliferation to help override the immune escape mechanisms developed by cancer cells. Emerging data from clinical trials of TCEs continue to provide insights on the efficacy and safety profiles of this class of therapy, and recent efforts have focused on optimizing clinical dose regimens to mitigate side effects related to overstimulation of the immune system, with particular emphasis on cytokine release syndrome (CRS) and neurotoxicity. For the currently approved TCEs, a key discovery was that by incrementally increasing the dose administered to a patient before reaching the target dose level, the body’s immune system could be primed in a more gradual manner, thereby modulating the balance between T cell activation and expansion, and cytokine-mediated efficacy and toxicity. This is known as step-up dosing, and various forms of this approach have been used to optimize TCE dose regimens to reduce the incidence or severity of CRS during clinical trials. |
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