Feb 2, 2023 17:34
1 yr ago
21 viewers *
Dutch term
Czech Republic
Qualified, experienced EN native speaker
Native in: English 
Works in: Czech to English, Slovak to English, German to English, and 3 more.
geen BCR-ABL fusiegenen passend bij t(9,22)
Dutch to English
Medical
Medical (general)
bone marrow test results
Can anyone help me with the sense of this please?
I see that we talk about "BCR-ABL fusion genes" in English but what do they mean by the "passend bij t(9,22)"?
It comes in a footnote on the "Uitslag moleculaire diagnostiek" under "Conclusie PCR Diagno"
I see that we talk about "BCR-ABL fusion genes" in English but what do they mean by the "passend bij t(9,22)"?
It comes in a footnote on the "Uitslag moleculaire diagnostiek" under "Conclusie PCR Diagno"
Proposed translations
(English)
| 4 | translocation (9,22) |
Jakub Rychter, PhD
|
| 5 | tandheelkunde |
PAGES Pages
|
| 3 | no BCR-ABL fusion genes consistent with the t(9;22) translocation |
Barend van Zadelhoff
|
Proposed translations
3 mins
Jakub Rychter, PhD
Spain
Spain
Native in Dutch
&
English
Specializes in field
Spain
Medical and Life Science translations
Native in: English 
, Dutch
Works in: German to English, Dutch to English
Related KudoZ points
:
4
Selected
translocation (9,22)
https://pubmed.ncbi.nlm.nih.gov/3054349/
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Note added at 12 mins (2023-02-02 17:47:07 GMT)
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No BCR-ABL fusion genes consistent with translocation (9,22).
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Note added at 12 mins (2023-02-02 17:47:07 GMT)
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No BCR-ABL fusion genes consistent with translocation (9,22).
Note from asker:
| Also really helpful – many thanks |
| Hi Jakub. According to ProZ, to reallocate the points to Barend (see the discusson) I need your agreement. Would you be willing to provide it? |
4 KudoZ points awarded for this answer.
Comment: "Thanks Jabub"
10 mins
Barend van Zadelhoff
Netherlands
Netherlands
Native in Dutch
Specializes in field
Netherlands
TR is the most intimate act of reading.
Native in: Dutch
Works in: English to Dutch, Dutch to English, Dutch
Related KudoZ points
:
494
no BCR-ABL fusion genes consistent with the t(9;22) translocation
I think you could solve it this way.
Genomic instability is an important underlying pathophysiological mechanism in chronic myeloid leukemia (CML). It results in formation of the Philadelphia
chromosome (Ph, t(9;22)(q34;q11)/BCR-ABL1) with various breakpoints and variant translocations, but also additional chromosomal abnormalities, and mutations in and outside the BCR-ABL1 kinase domain.
Understanding the diversity of chromosomal and molecular manifestations in CML is of importance for the clinician.
https://www.cmylife.nl/sites/default/files/2021-09/NTvH Gene...
The hallmark of chronic myeloid leukemia (CML) is the BCR-ABL fusion gene, which is usually formed as a result of the t(9;22) translocation.
https://pubmed.ncbi.nlm.nih.gov/10648381/
Genomic instability is an important underlying pathophysiological mechanism in chronic myeloid leukemia (CML). It results in formation of the Philadelphia
chromosome (Ph, t(9;22)(q34;q11)/BCR-ABL1) with various breakpoints and variant translocations, but also additional chromosomal abnormalities, and mutations in and outside the BCR-ABL1 kinase domain.
Understanding the diversity of chromosomal and molecular manifestations in CML is of importance for the clinician.
https://www.cmylife.nl/sites/default/files/2021-09/NTvH Gene...
The hallmark of chronic myeloid leukemia (CML) is the BCR-ABL fusion gene, which is usually formed as a result of the t(9;22) translocation.
https://pubmed.ncbi.nlm.nih.gov/10648381/
Note from asker:
| Really helpful |
| Went with Jakub's answer because he was first Barend, but thanks for that extra information - really helpful |
49 mins
PAGES Pages
France
France
Specializes in field
France
Professionnal Results Only
Native in: French (Variant: Standard-France)
Works in: Italian to French, English to French
tandheelkunde
Hallo,
Ik ben Belgisch staatsburger, geboren in Brussel. Ik ben al 40 jaar tandarts
Ik ben Belgisch staatsburger, geboren in Brussel. Ik ben al 40 jaar tandarts
Discussion
It suffices to me that you recognize the 'inconsistency'. :-)
This whole Kudoz game is designed from the perspective of competition (being first, being best [providing the best answer], winning points, boosting your profile).
And I fall for it, I want to win.
It's a vulnerability, it may induce a 'Calimero effect'. :-)
https://www.youtube.com/watch?v=77HpxfMTJL8 :-)
But a couple of points.
- 'translocation' was not the problem, 'passend bij' was the question, everyone knows that 't(9,22)' stands for a translocation.
- I arrived at my answer independently, was busy gathering evidence while the other answer was posted.
- I gathered evidence in order to explain why 'consistent with' could be used. I mean, that's the point, no?