English to Italian Science Medical (general) genetics

DCC-2618 comprehensively and potently inhibits a broad range of primary and secondary mutants of KIT and PDGFRA kinases, including KIT primary initiating mutations in exons 9 and 11 and secondary mutations in exons 13 and 14 of the KIT Switch Pocket region and in exons 17 and 18 of the activation loop conformation controlling Switch.