Nov 19, 2016 18:45
7 yrs ago
English term

infant

English to Japanese Medical Medical (general) Non-Clinical trial
動物試験にでてくるのですが、

Infant

Neonates

Juvenile

の使い分けについて正確にお願いいたします。

今のところ、Neonatesを新生動物、Juvenileを幼若動物としていたのですが、Infantが出てきてしまって困っております。
人間だと乳児だと思うのですが、動物は児ではないので困っています。

もし幼若をInfantにするべきなのならJuvenileに別の訳をお願いします。。
Proposed translations (Japanese)
4 乳子[仔]

Proposed translations

3 hrs

乳子[仔]

英和実験動物学用語集での「Infant」の意味
infant
乳子[仔,児]
http://ejje.weblio.jp/content/Infant

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Note added at 4時間 (2016-11-19 22:59:59 GMT)
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juvenile: 若年の,幼年の、幼体

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Note added at 8時間 (2016-11-20 02:46:34 GMT)
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英和実験動物学用語集での「neonate」の意味
neonate
新生子[仔,児]
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Reference comments

57 mins
Reference:

periods within first six months of life

response to a painful stimulus. is has also been shown in laboratory animals.
Thee term paediatric generally refers to the first six months of life. Due to important physiological changes which occur during this time frame, a further
demarcation is defined as:
neonatal (0–2 weeks),
infant (2–6 weeks)
weanling, (6–12 weeks) and
juvenile (3–6 months).
http://www.wsava.org/sites/default/files/Neonatal and pediat...


Stage name in Rat/Human
neonatal/newborn (0–7 days),
infantile/infannt (8-20 days)
juvenile/child (21-32 days)
peripubertal/adolescent (31-55 days)
late puberty/adolescent (56-70 days).

https://books.google.hu/books?id=Ko9CCQAAQBAJ&pg=PR12&lpg=PR...

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Note added at 1 hr (2016-11-19 19:47:45 GMT)
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PDF]「小児用医薬品のための幼若動物を用いた非臨床安全性試験ガイドライン ...
search.e-gov.go.jp/servlet/PcmFileDownload?seqNo...
な考え方を示したものであり、成熟動物を用いた試験などの. 非臨床成績や ... 実施すべきとしているものです。 3. 2 1 ・背景. - ... E11 guideline i.e. neonate, infant, child, adolescent. Then use ... adolescence and accordingly more likely that juvenile animal ... 小児用医薬品のための幼若動物を用いた非臨床安全性試験ガイドライン(案)の意見の募集について」 ..... 医薬品の臨床試験及び製造販売承認申請のための非臨床.

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Note added at 1 hr (2016-11-19 19:59:34 GMT)
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「適用小児と幼若動物の比較(毒性標的、器官・機能発達、動
態の相違)」の意味がわかりにくい。 Q&AのQ4に記載しました。

OVERVIEW OF COMMENTS RECEIVED ON DRAFT GUIDELINE ON THE NEED FOR NON-CLINICAL TESTING IN
JUVENILE ANIMALS OF HUMAN PHARMACEUTICALS FOR PAEDIATRIC INDICATIONS
http://www.ema.europa.eu/docs/en_GB/document_library/Other/2...
In general, current preclinical study programs generate considerable
information relevant to a consideration of safety in paediatric patients.
Rats used in repeat dose and reproduction studies for example
normally commence treatment at 5 to 6 weeks of age. As sexual
maturity in the rat is achieved at approximately 13 weeks, these
animals are sexually and developmentally immature at the start of
treatment. Commencement of treatment at 4 weeks of age in some of
these studies would significantly enhance the information obtainable
from them without a need for increased animal usage or additional
studies
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