English to Russian Medical Medical: Pharmaceuticals

Median PFS was 7.5 months (95% CI:
5.2NE) in patients (n=19 based on central laboratory analyses) with HER2positive disease in the palbociclib plus fulvestrant arm (Study 1023 CSR, Table 14.6.2.1).
It is well known that assessment of ER and progesterone receptor using IHC is facing challenges, such as the extent of assay validation, sample processing, and subjectivity involved in measurement and interpretation.,,, Reports from multinational cooperative groups have shown that concordance between ER and progesterone receptor testing at the primary institutional site of patient enrollment and *high volume central laboratories* is about 81.7% to 87.9%.