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The Federal Insecticide, Fungicide, and Rodenticide Act of 1972, 7 U.S.C. § 136 et seq. (amended somewhat in 1996 by the Food Quality Protection Act) is a United States federal law that set up the basic U.S. system of pesticide regulation to protect applicators, consumers and the environment. It is administered by the Environmental Protection Agency (EPA) and the appropriate environmental agencies of the respective states. It superseded the Federal Insecticide Act of 1910 and the Federal Insecticide, Fungicide, and Rodenticide Act of 1947.

1. FIFRA established registration for all pesticides, which is only done after a period of data collection to determine the effectiveness for its intended use, appropriate dosage, and hazards of the particular material. When registered, a label is created to instruct the final user the proper usage of the material. It is unlawful to use any pesticide not in accordance with the label; in other words, the label is the law. [1]

Label directions are designed to maximize the effectiveness of the product, while protecting the applicator, consumers, and the environment. Critics of the process point out, on the one hand that the research to produce the label is entirely done by the manufacturer and not much checking is done on its accuracy. On the other hand some consider the process too strict. It costs millions of dollars and often several years to register a pesticide, which limits production only to large players. Likewise many smaller or specialty uses are never registered, because the companies do not consider the potential sales sufficient to justify the investment.