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une CI50 en bas de 20 à 30 micro molaires/aux 12 heures.
ne préjuge en rien de
Oct 9, 2005 19:20
18 yrs ago
1 viewer *
French term

les deux étant plus faible dose.

French to English Medical Genetics FRE Canadian/transcript of a meeting on the treatment of CMV in transplant patients
Si on a des hauts niveaux de résistances ou des mutations dans le gène qui code pour l’ADN polymérase ou nous avons une maladie à CMV qui est « life threatening » on devrait d’amblée « switcher » notre traitement pour le foscarnet ou une combinaison de foscarnet et Ganciclovir, ** les deux étant plus faible dose. **

what's (at) a lower dose: foscarnet, or the combination of foscarnet and ganciclovir, or both?
What I don't understand is, if it's life-threatening or there's high resistance to the drug, why lower the dose???
Earlier in the text, he prescribes the use of ganciclovir for low resistance/non life-threatening, so you see my dilemma...

anyone knows about/understands this? I'm starting to feel really stupid... :-(
Proposed translations (English)
4 +2 see note
5 +1 both drugs, at a lower dose

Discussion

Sandra C. (asker) Oct 10, 2005:
thank you both!
Georges Tocco Oct 9, 2005:
yes both at a lower dose definitly see note
Richard Benham Oct 9, 2005:
"Les deux" can only mean both drugs mentioned, but it doesn't make sense that way unless there is mention somewhere else of using Ganciclovir alone, in which case it would mean using both, but each at a lower dose than if you were using it alone.
Dr Sue Levy (X) Oct 9, 2005:
les deux � une plus faible dose? i.e. when used in combination

Proposed translations

+2
21 mins
French term (edited): les deux �tant plus faible dose.
Selected

see note

they will switch to a combine treatment because ganciclovir alone is bot efficacious since the virus is resistant to it. Therefore they need another drug. They still want to still use the drug however because the patienst might still have some forms of the virus that is not resistant to the drug. Should they stop it altogether that virus might then take over.
So they still want to use both drug at a low dose but not terminate the ganciclovir altogether

--------------------------------------------------
Note added at 29 mins (2005-10-09 19:50:33 GMT)
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They want to lower the dose of ganciclovir becaue it does have some side effects. If it is not effective against the mutated virus there is no need to keep it high.
Peer comment(s):
agree sarahl (X) : yes they're probably trying to determine the LED, this class of meds can have SAE.
3 hrs
agree Sylvia Smith
10 hrs
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "merci Georges!"
+1
1 hr
French term (edited): les deux �tant plus faible dose.

both drugs, at a lower dose

Often when more than one drug is used in combination therapy, it is necessary to lower the dose of each because of overlapping, cumulative side effects. Furthermore, there are many examples of drug combinations that outperform the sum of the performance of each (when used alone) because of the complimentary modes of action of the respective medications. For example, each drug may attack a different enzyme of the targeted pathogen, and while the germ may have evolved defences against one or the other, in many cases, not both.
Peer comment(s):
agree Sylvia Smith : yes, this is a way to phrase what Georges said above
9 hrs
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