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Introduction

Doxazosin is a long-acting, selective alpha-1 adrenoceptor antagonist, indicated for the treatment of hypertension and benign prostatic hyperplasia (BPH).

It is structurally related to prazosin and terazosin, but distinctive in that it has a *hydroxy terminus* and an extended half-life of elimination.

The product is available in global markets as 0.5, 1, 2, 4 and 8 mg tablets for the standard formulation, and as 4 or 8 mg tablets for the Gastrointestinal Therapeutic System (GITS) formulation, a controlled-release formulation of doxazosin based on osmotic push technology.