GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||||
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11:44 Sep 24, 2020 |
German to English translations [PRO] Medical - Medical (general) | |||||||
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| Selected response from: Marga Shaw United Kingdom Local time: 19:12 | ||||||
Grading comment
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Summary of answers provided | ||||
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5 +1 | having successfully navigated the nadir |
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3 +1 | through the nadir |
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3 | passing the nadir |
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having successfully navigated the nadir Explanation: This is talking about using the medication until the patient has come through, or successfully navigated, the nadir, or worst, of the condition or symptoms. It seems to be quite a common term used in cancer treatment.: https://csn.cancer.org/node/314402 https://historicengland.org.uk/whats-new/debate/navigating-the-nadir/ |
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passing the nadir Explanation: With regard to chemotherapy specifically, it describes the point at which blood cell counts are at their lowest after a chemotherapy treatment. It is commonly referred to as the "nadir period" or simply "nadir" among healthcare workers and patients. Nadir What Is Nadir? When discussing chemotherapy side effects often you will hear the word nadir, mainly in reference to the blood counts, particularly white blood cell count and platelet count. Nadir basically means low point, however further explanation may clarify this term in connection with chemotherapy treatment. ... http://chemocare.com/chemotherapy/what-is-chemotherapy/what-... Examples: In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen 1 - 2 days after initiation of filgrastim therapy. However, for a sustained therapeutic response, filgrastim therapy should not be discontinued before the expected nadir has passed and the neutrophil count has recovered to the normal range. Premature discontinuation of filgrastim therapy, prior to the time of the expected neutrophil nadir, is not recommended. https://webcache.googleusercontent.com/search?q=cache:in9ahv... Daily dosing with Neupogen should continue until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range. https://www.medicines.org.uk/emc/product/3000/smpc/print#gre... GCSF should not be stopped before the nadir. The nadir usually occurs 7-10 days after the start of chemotherapy. If the patient’s white cell count rises significantly before the nadir, discuss this with the PTC team. GCSF is often continued for a minimum of 7 days and until neutrophils > 1 x 109/L for 2 or 3 consecutive days after the nadir. The platelet count is useful to identify when the nadir has passed, as the platelet count will begin to rise, and is unaffected by GCSF. https://www.piernetwork.org/gcsf.html |
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through the nadir Explanation: The German says "bis" Durchschreiten des Nadir. That needs to be reflected in the answer. Compare with this: "Administer daily NEUPOGEN (filgrastim) through the nadir until neutrophil recovery." https://www.neupogenhcp.com/neutrophil-recovery/ |
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