Durchschreiten des Nadirs

English translation: passing the nadir

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
German term or phrase:Durchschreiten des Nadirs
English translation:passing the nadir
Entered by: Marga Shaw

11:44 Sep 24, 2020
German to English translations [PRO]
Medical - Medical (general)
German term or phrase: Durchschreiten des Nadirs
Chemotherapy protocol
Filgrastim 5 mg s.c. bis Durchschreiten des Nadirs
Assanett
Local time: 20:12
passing the nadir
Explanation:
With regard to chemotherapy specifically, it describes the point at which blood cell counts are at their lowest after a chemotherapy treatment. It is commonly referred to as the "nadir period" or simply "nadir" among healthcare workers and patients.

Nadir
What Is Nadir?

When discussing chemotherapy side effects often you will hear the word nadir, mainly in reference to the blood counts, particularly white blood cell count and platelet count. Nadir basically means low point, however further explanation may clarify this term in connection with chemotherapy treatment. ...
http://chemocare.com/chemotherapy/what-is-chemotherapy/what-...

Examples:
In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen
1 - 2 days after initiation of filgrastim therapy. However, for a sustained therapeutic response,
filgrastim therapy should not be discontinued before the expected nadir has passed and the neutrophil
count has recovered to the normal range. Premature discontinuation of filgrastim therapy, prior to the
time of the expected neutrophil nadir, is not recommended.
https://webcache.googleusercontent.com/search?q=cache:in9ahv...

Daily dosing with Neupogen should continue until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range.
https://www.medicines.org.uk/emc/product/3000/smpc/print#gre...

GCSF should not be stopped before the nadir. The nadir usually occurs 7-10 days after the start of chemotherapy. If the patient’s white cell count rises significantly before the nadir, discuss this with the PTC team. GCSF is often continued for a minimum of 7 days and until neutrophils > 1 x 109/L for 2 or 3 consecutive days after the nadir.
The platelet count is useful to identify when the nadir has passed, as the platelet count will begin to rise, and is unaffected by GCSF.
https://www.piernetwork.org/gcsf.html

Selected response from:

Marga Shaw
United Kingdom
Local time: 19:12
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
5 +1having successfully navigated the nadir
Cillie Swart
3 +1through the nadir
Michael Martin, MA
3passing the nadir
Marga Shaw


  

Answers


9 mins   confidence: Answerer confidence 5/5 peer agreement (net): +1
having successfully navigated the nadir


Explanation:
This is talking about using the medication until the patient has come through, or successfully navigated, the nadir, or worst, of the condition or symptoms.

It seems to be quite a common term used in cancer treatment.: https://csn.cancer.org/node/314402


    https://historicengland.org.uk/whats-new/debate/navigating-the-nadir/
Cillie Swart
South Africa
Local time: 21:12
Native speaker of: Native in EnglishEnglish
PRO pts in category: 62

Peer comments on this answer (and responses from the answerer)
agree  philgoddard: I think it could be expressed more concisely, though - perhaps "until past the nadir".
47 mins
Login to enter a peer comment (or grade)

1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5
passing the nadir


Explanation:
With regard to chemotherapy specifically, it describes the point at which blood cell counts are at their lowest after a chemotherapy treatment. It is commonly referred to as the "nadir period" or simply "nadir" among healthcare workers and patients.

Nadir
What Is Nadir?

When discussing chemotherapy side effects often you will hear the word nadir, mainly in reference to the blood counts, particularly white blood cell count and platelet count. Nadir basically means low point, however further explanation may clarify this term in connection with chemotherapy treatment. ...
http://chemocare.com/chemotherapy/what-is-chemotherapy/what-...

Examples:
In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen
1 - 2 days after initiation of filgrastim therapy. However, for a sustained therapeutic response,
filgrastim therapy should not be discontinued before the expected nadir has passed and the neutrophil
count has recovered to the normal range. Premature discontinuation of filgrastim therapy, prior to the
time of the expected neutrophil nadir, is not recommended.
https://webcache.googleusercontent.com/search?q=cache:in9ahv...

Daily dosing with Neupogen should continue until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range.
https://www.medicines.org.uk/emc/product/3000/smpc/print#gre...

GCSF should not be stopped before the nadir. The nadir usually occurs 7-10 days after the start of chemotherapy. If the patient’s white cell count rises significantly before the nadir, discuss this with the PTC team. GCSF is often continued for a minimum of 7 days and until neutrophils > 1 x 109/L for 2 or 3 consecutive days after the nadir.
The platelet count is useful to identify when the nadir has passed, as the platelet count will begin to rise, and is unaffected by GCSF.
https://www.piernetwork.org/gcsf.html



Marga Shaw
United Kingdom
Local time: 19:12
Specializes in field
Native speaker of: German
PRO pts in category: 700
Login to enter a peer comment (or grade)

3 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
through the nadir


Explanation:
The German says "bis" Durchschreiten des Nadir. That needs to be reflected in the answer.

Compare with this:
"Administer daily NEUPOGEN (filgrastim) through the nadir until neutrophil recovery." https://www.neupogenhcp.com/neutrophil-recovery/

Michael Martin, MA
United States
Local time: 15:12
Works in field
Native speaker of: Native in GermanGerman, Native in EnglishEnglish
PRO pts in category: 159

Peer comments on this answer (and responses from the answerer)
agree  Anne Schulz
1 day 15 hrs
  -> Thanks, Anne!
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