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excision repair cross-complementing 1 (ERCC1) gene

English translation: ---------------------------------------------------------------

08:43 Jul 23, 2004
English language (monolingual) [PRO]
Science - Genetics
English term or phrase: excision repair cross-complementing 1 (ERCC1) gene
For example, high levels of the gene product for the excision repair cross-complementing 1 (ERCC1) gene, which is crucial in the repair of cisplatin (CDDP)-DNA adducts, is reported to negatively influence the effectiveness of CDDP-based therapy for gastric and ovarian cancers
nereveb
Selected answer:---------------------------------------------------------------
Explanation:
The excision repair cross-complementing 1 (ERCC1) gene is coding for a nucleotide excision repair protein involved in the repair of radiation- and chemotherapy-induced DNA damage. Overexpression of the excision repair cross-complementing 1 (ERCC1) gene,
is crucial in the repair of cisplatin (CDDP)-DNA adducts, however, it is reported to negatively influence the effectiveness of CDDP-based therapy for gastric and ovarian cancers. Recent evidence indicates that Gemcitabine (Gem) may modulate ERCC1 nucleotide excision repair activity, and down-regulation of DNA repair activity by ERCC1 antisense RNA reportedly inhibits synergism of CDDP/Gem. (In patients with non-small cell lung cancer (NSCLC), low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy. )


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Note added at 8 hrs 59 mins (2004-07-23 17:43:45 GMT)
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http://clincancerres.aacrjournals.org/ cgi/content/full/10/11/3794
http://www.asco.org/ac/1,1003,_12-002636-00_ 18-0016-00_19-00540,00.asp
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=10741696&dopt=Abstractb -
Selected response from:

Elena Petelos
United Kingdom
Local time: 19:02
Grading comment
Graded automatically based on peer agreement.
4 KudoZ points were awarded for this answer



SUMMARY OF ALL EXPLANATIONS PROVIDED
5 +2---------------------------------------------------------------
Elena Petelos
4DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional......
Saleh Chowdhury, Ph.D.


Discussion entries: 3





  

Answers


2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
excision repair cross-complementing 1 (ercc1) gene
DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional......


Explanation:
DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse. For more information, pls have a look at the website:


    Reference: http://dev.biologists.org/cgi/content/full/130/2/369
Saleh Chowdhury, Ph.D.
Bangladesh
Local time: 00:02
Native speaker of: Native in BengaliBengali
Login to enter a peer comment (or grade)

8 hrs   confidence: Answerer confidence 5/5 peer agreement (net): +2
excision repair cross-complementing 1 (ercc1) gene
---------------------------------------------------------------


Explanation:
The excision repair cross-complementing 1 (ERCC1) gene is coding for a nucleotide excision repair protein involved in the repair of radiation- and chemotherapy-induced DNA damage. Overexpression of the excision repair cross-complementing 1 (ERCC1) gene,
is crucial in the repair of cisplatin (CDDP)-DNA adducts, however, it is reported to negatively influence the effectiveness of CDDP-based therapy for gastric and ovarian cancers. Recent evidence indicates that Gemcitabine (Gem) may modulate ERCC1 nucleotide excision repair activity, and down-regulation of DNA repair activity by ERCC1 antisense RNA reportedly inhibits synergism of CDDP/Gem. (In patients with non-small cell lung cancer (NSCLC), low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy. )


--------------------------------------------------
Note added at 8 hrs 59 mins (2004-07-23 17:43:45 GMT)
--------------------------------------------------

http://clincancerres.aacrjournals.org/ cgi/content/full/10/11/3794
http://www.asco.org/ac/1,1003,_12-002636-00_ 18-0016-00_19-00540,00.asp
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=10741696&dopt=Abstractb -


    Reference: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Re...
    www.pcabc.upmc.edu/biomarkers/ Proposed_BioMarkers_Table.doc
Elena Petelos
United Kingdom
Local time: 19:02
Specializes in field
Native speaker of: Greek
PRO pts in category: 8
Grading comment
Graded automatically based on peer agreement.

Peer comments on this answer (and responses from the answerer)
agree  Lamprini Kosma
4 days
  -> Thanks! :-)
agree  Calliope Sofianopoulos (X)
10 days
  -> Thanks!:-)
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