Deregulated nutrient sensing

Turkish translation: besin değerini algılama sürecinin/mekanizmasının bozulması

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:Deregulated nutrient sensing
Turkish translation:besin değerini algılama sürecinin/mekanizmasının bozulması
Entered by: hfilik

13:38 Nov 15, 2016
English to Turkish translations [PRO]
Medical - Nutrition
English term or phrase: Deregulated nutrient sensing
Metabolism and its byproducts, over time, damage cells via oxidative stress, ER stress, calcium signaling, and mitochondrial dysfunction. Therefore, organisms depend on multiple nutrient sensing pathways to make sure that the body takes in just the right amount of nutrition – not too much, not too little. However, these damaging events also deregulate the nutrient-sensing molecules and downstream pathways. A misguided hypothalamus may signal for greater food intake, then, when the body doesn’t really require it. Age-related obesity, diabetes and other metabolic syndromes result. To make things even worse, obesity- and diabetes-related chronic inflammation, operating via JNK and IKK crosstalk, can deregulate nutrient sensing further.
hfilik
Türkiye
Local time: 12:43
besin değerini algılama sürecinin/mekanizmasının bozulması
Explanation:
besin değerini algılayan moleküllerin bozulması
Selected response from:

Zeki Güler
Local time: 09:43
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
5Kısıtlanmayan besin algılaması
Salih YILDIRIM
4deregüle besin sensörleri
MS13 (X)
3besin değerini algılama sürecinin/mekanizmasının bozulması
Zeki Güler


  

Answers


6 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
deregulated nutrient sensing
besin değerini algılama sürecinin/mekanizmasının bozulması


Explanation:
besin değerini algılayan moleküllerin bozulması

Zeki Güler
Local time: 09:43
Native speaker of: Native in TurkishTurkish
PRO pts in category: 4
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16 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
deregulated nutrient sensing
deregüle besin sensörleri


Explanation:
http://acikerisim.deu.edu.tr/xmlui/bitstream/handle/12345/10...


...Normal hücrelerde, besin sensörü PI3K’ın downstreamindeki rapamisin kinazın memeli hedefi (mTOR) , primer olarak otofajiyi regüle eder (24)...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857321/pdf/ukm...


...PI3K-mTOR nutrient sensing pathways also determined expression of the chemokine receptor CCR7 and regulate lymphocyte trafficking in vivo...

http://acikerisim.istanbulbilim.edu.tr/bitstream/handle/1144...


...PI3K/PTEN/AKT sinyal yolaklar kanserde sklkla deregüle olur...

Yukarıdaki makalelerde nutrient sensing özelliği olan inhibitör ve yolaklar için "besin sensörü" ifadesi kullanılabilmektedir. Ayrıca "deregulated" için türkçe kaynaklarda sıklıkla "deregüle" ifadesi kullanılmaktadır.

Buna göre "deregulated nutrient sensing (molecules / pathways)" için "deregüle besin sensörleri" kullanılabilir sanırım.



    Reference: http://acikerisim.deu.edu.tr/xmlui/bitstream/handle/12345/10...
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857321/pdf/ukmss-1819.pdf
MS13 (X)
Türkiye
Local time: 12:43
Works in field
Native speaker of: Turkish
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1 day 1 hr   confidence: Answerer confidence 5/5
deregulated nutrient sensing
Kısıtlanmayan besin algılaması


Explanation:
Derdim.

Salih YILDIRIM
United States
Local time: 05:43
Works in field
Native speaker of: Native in TurkishTurkish
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