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affinity maturation

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00:55 Oct 28, 2020
English to Turkish translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
5afinite matürasyonu
mediko06
4Afinite olgunlaşması
Amir Akbarpour Reihani


  

Translations offered


4 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
Afinite olgunlaşması


Definition from Netinbag:
Afinite olgunlaşması bir bağışıklık sistemi tepkisidir. Bu terim, B hücreleri adı verilen bir tür lenfositin etkilerini ve antijene maruz kalmaya nasıl tepki verdiklerini açıklar. Bu hücre değişimi ve seçimi sürecidir.

Example sentence(s):
  • Etkenle vücudun ilk karşılaşmasında ortaya çıkan primer immün yanıtta salgılanan antikorların Kd değeri 10-6-10-9 M arasındayken, etkenle tekrarlayan karşılaşmalarda ortaya çıkan sekonder immün yanıtta salgılanan antikorların afinitesi yükselir: 10-8-10-11M. Antikorun antijen bağlama gücünde ortaya çıkan bu artışa “afinite olgunlaşması” denir. - Acikders  
  • Afinite olgunlaşması olarak da isimlendirilen bu yöntem seçilen antijenler ile antikorların afinitesini arttırmak için bağışık sisteme izin verir. - Firat  
Amir Akbarpour Reihani
Local time: 01:00
Native speaker of: Native in Persian (Farsi)Persian (Farsi)
PRO pts in category: 4
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2 days 15 hrs   confidence: Answerer confidence 5/5
afinite matürasyonu


Definition from online immunology dictionary:
Afinite matürasyonu: Bir antijanle önceden karşılaşan bellek hücrelerinin aynı antijenle yeniden karşılaştığında daha yüksek afinitesi olması ve daha kuvvetli cevap vermesi

Example sentence(s):
  • Afinite matürasyonu bir protein antijen için Th hücre-bağımlı immün yanıt sırasında, antijene gittikçe daha yüksek afinite ile bağlanan antikor üretilmesini ifade eder ve antijeni daha iyi elimine eden veya nötralize eden antikorların üretimine olanak tanır - medical article  
  • Germinal merkezʼde antijenik uyarıma bağlı lenfosit hücre klonunun seçilmesi, somatik hipermutasyon ve Ig H zincir C bölgesi izotipik değişimi ile yüksek afiniteli antikorların oluşumu afinite matürasyonu olarak bilinmektedir. - medical article  
mediko06
Türkiye
Local time: 00:30
Native speaker of: Turkish
PRO pts in category: 54
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