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gene silencing

Swedish translation: genavstängning

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:gene silencing
Swedish translation:genavstängning

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13:57 Feb 9, 2010
English to Swedish translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Medical (general), Genetics
English term or phrase: gene silencing
Definition from MedicineNet, Inc.:
Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent. The process of gene silencing is important for the differentiation of many different types of cells.

Example sentence(s):
  • Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. biotech-info.net
  • The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? The Thomson Corporation
  • In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. ScienceDaily LLC
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genavstängning
Definition:
När en gen tystas ned, genom t.ex. RNA-interferens, talar man på svenska om genavstängning (gene silencing). Hos växter som används som livsmedel kan man blockera eller reducera bildningen av oönskade ämnen, till exempel sådana som kan framkalla allergi. Djurmodeller av vissa sjukdomar, till exempel högt blodkolesterolvärde, kan påverkas gynnsamt genom genavstängning. I en klinisk prövning använder man RNA-interferens för att blockera en gen som är verksam vid en näthinnesjukdom.
Selected response from:

egj_translation
Sweden
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4 KudoZ points were awarded for this answer



Summary of translations provided
4 +3genavstängning
egj_translation


  

Translations offered


1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
genavstängning


Definition from Nationalencyklopedin: Nobelpriset 2006:
När en gen tystas ned, genom t.ex. RNA-interferens, talar man på svenska om genavstängning (gene silencing). Hos växter som används som livsmedel kan man blockera eller reducera bildningen av oönskade ämnen, till exempel sådana som kan framkalla allergi. Djurmodeller av vissa sjukdomar, till exempel högt blodkolesterolvärde, kan påverkas gynnsamt genom genavstängning. I en klinisk prövning använder man RNA-interferens för att blockera en gen som är verksam vid en näthinnesjukdom.

Example sentence(s):
  • Djurmodeller av vissa sjukdomar, till exempel högt blodkolesterolvärde, kan påverkas gynnsamt genom genavstängning. - Nationalencyklopedin  
  • Imprinting kontroll regionen Kcnq1: Ett paradigm för antisenstranskription-medierad genavstängning The Kcnq1 imprinting control region: A paradigm for antisense transcription-mediated bi-directional silencing - Vetenskapsrådets projektdatabas  
  • Störd genomisk prägling innebär att det är något fel på mekanismen för föräldraberoende genavstängning. - Ågrenska Nyhetsbrev 165  

Explanation:
Se även Karolinska institutet, gene silencing -> genavstängning:
http://mesh.kib.ki.se/swemesh/show.swemeshtree.cfm?mesh_eng=...

http://mesh.kib.ki.se/swemesh/expand.term.cfm?Mesh_No=G05.35...
egj_translation
Sweden
Local time: 00:01
Native speaker of: Native in SwedishSwedish
PRO pts in category: 4

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Linnéa Holmén
16 hrs
Yes  Angelica Kjellström
1 day 10 mins
Yes  Janis Abens
1 day 47 mins
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