rescues T-cell signaling

Russian translation: ...восстанавливая / сохраняя активность Т-клеточных сигнальных путей

16:58 Aug 6, 2020

English to Russian translations [PRO]
Medical - Medical (general) / Immunology

English term or phrase: rescues T-cell signaling

An isolated antibody or antigen-binding fragment that blocks PD-1-induced T-cell down regulation and rescues T-cell signaling.

PD-1 – это рецептор на поверхности Т-лимфоцитов. Из Википедии: PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).

Антитела, о которых идет речь, связываются с PD-1 и не дают этим рецепторам связываться с лигандами (PD-L1 и PD-L2), благодаря чему Т-клетки продолжают свою активность.

"Сохраняет активность сигнальных путей Т-клеток"?

lerethel KudoZ activity Questions: 209 (none open) (10 closed without grading) Answers: 3 Russian Federation
Local time: 21:56

Russian translation:...восстанавливая / сохраняя активность Т-клеточных сигнальных путей

Explanation:
Поскольку антитело препятствует ингибированию, то оно, соответственно, восстанавливает / поддерживает / сохраняет активность.

Selected response from:

Natalie
Poland
Local time: 20:56

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...восстанавливая / сохраняя активность Т-клеточных сигнальных путей

Natalie

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19 mins confidence:

peer agreement (net): +1

rescues t-cell signaling

...восстанавливая / сохраняя активность Т-клеточных сигнальных путей

Natalie
Poland
Local time: 20:56
Specializes in field
Native speaker of: Russian
PRO pts in category: 6006

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rescues T-cell signaling

Russian translation: ...восстанавливая / сохраняя активность Т-клеточных сигнальных путей

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rescues T-cell signaling

Russian translation: ...восстанавливая / сохраняя активность Т-клеточных сигнальных путей

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