multiple cytochromes P450
Romanian translation: multiple izoforme ale citocromului P450
| GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||||
|---|---|---|---|---|---|---|
|
| 10:59 Mar 21, 2010 |
| English to Romanian translations [PRO] Medical - Medical: Pharmaceuticals | |||||||
|---|---|---|---|---|---|---|---|
|
| ||||||
|  Selected response from: Antonia Toth Local time: 04:50 | ||||||
Grading comment
| |||||||
| Summary of answers provided | ||||
|---|---|---|---|---|
| 4 +1 | mai multe tipuri/forme de citocrom P450 |
|
| Summary of reference entries provided | |||
|---|---|---|---|
| multiple cytochromes P450 |
|
| Discussion entries: 1 | |
|---|---|
Answers
2 hrs confidence: 
peer agreement (net): +1
peer agreement (net): +1| multiple cytochromes p450 mai multe tipuri/forme de citocrom P450 Explanation: Caracteristica cea mai importanta a citocromului P450 este reprezentata de marea lui diversitate; membrii acestei "superfamilii" au o larga si sovraponibila specificitate de substrat, precum si capacitatea de a interactiona cu majoritatea structurilor chimice. http://www.emcb.ro/article.php?story=20050730223027175 Genetic variants of other CYP450 enzymes may also affect the formation of clopidogrel's active metabolite. http://products.sanofi-aventis.us/plavix/plavix.html |
| |
Grading comment
| ||
| Login to enter a peer comment (or grade) | ||
Reference comments
8 hrs |
| Reference: multiple cytochromes P450 Reference information: Mammals express multiple cytochromes P450 simultaneously in a variety of tissues, including the liver, kidney, lung, adrenal, gonads, brain, and most others. For cytochromes P450 that are expressed in many tissues or cell types, the tissue/cell type-specific expression might be associated with their special physiological roles. Several cytochrome P450 enzymes are found not only in different cell types and tissues, but also in different subcellular compartments. Generally, all mammalian cytochrome P450 enzymes are membrane bound. The two major groups are represented by microsomal cytochromes P450 that reside in the endoplasmic reticulum, and mitochondrial cytochromes P450, that reside in the inner mitochondrial membrane. http://www.mitochondrial.net/showabstract.php?pmid=17097232 -------------------------------------------------- Note added at 8 ore (2010-03-21 19:56:14 GMT) -------------------------------------------------- Cred că am nevoie de un timp de reflecţie în seara asta :-) După ce am afişat referinţa şi am recitit fraza ta, am început să am dubii...nu se potriveşte în context. Sistemul enzimatic citocrom P450 este unul singur (complex, superfamilie, etc.) format din mai multe izoenzime. Eu aş traduce "mai multe izoenzime ale citocromului P450"... -------------------------------------------------- Note added at 9 ore (2010-03-21 20:06:16 GMT) -------------------------------------------------- Între timp, mi-am amintit că izoenzimele respective apar frecvent menţionate ca izoforme...(culmea este că am tradus o mulţime despre izoformele citocromului P450...) ...deci este foarte corect să spui: numeroase/multiple izoforme are citocromului P450 Iată câteva exemple: De metabolismul nelfinavirului raspund in vitro multiple izoforme ale citocromului P-450, inclusiv CYP3A. www.pcfarm.ro/prospect.php?id=3294 În organismul uman citocromul P450 există sub diferite izoforme (la momentul actual sunt cunoscute mai mult de 400) codate de o diversitate de gene library.usmf.md/downloads/anale/vol_03/3_Gastroenterologie.doc |
| ||
Note to reference poster
| |||
| Login to enter a peer comment (or grade) | |||
Login or register (free and only takes a few minutes) to participate in this question.
You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.
KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.
See also:
Search millions of term translations