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affinity maturation

Portuguese translation: maturação de afinidade

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00:56 Oct 28, 2020
English to Portuguese translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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Question posted on behalf of translation team:
GBK medical and pharma specialistsGBK medical and pharma specialists


This question is closed

Portuguese translation:maturação de afinidade
Definition:
A maturação de afinidade (em inglês affinity maturation) é um processo do sistema imunológico de mamíferos, cujo resultado é a melhora da eficiência da resposta imune em um segundo contato com um antígeno.
Selected response from:

Liane Lazoski
Brazil
Grading comment
4 KudoZ points were awarded for this answer



Summary of translations provided
4 +3maturação de afinidade
Liane Lazoski


  

Translations offered


8 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
maturação de afinidade


Definition from Wikipedia:
A maturação de afinidade (em inglês affinity maturation) é um processo do sistema imunológico de mamíferos, cujo resultado é a melhora da eficiência da resposta imune em um segundo contato com um antígeno.

Example sentence(s):
  • A maturação da afinidade é o processo pelo qual a afinidade dos anticorpos produzidos em resposta a um antígeno proteico aumenta com a exposição prolongada ou repetida a esse antígeno. - Passei direto  
  • - Rede neural Booleana com processos de crescimento, poda e atualização de pesos inspirados no princípio da seleção clonal e maturação de afinidade - Unicamp  
  • A resposta humoral frente a Ag proteicos requer o reconhecimento do antígeno pelos LT auxiliares e sua cooperação com os LB antígeno-específicos, estimulando a expansão clonal dos LB, a mudança de classe, a maturação de afinidade e a diferenciação em LB de memória. - Scielo  
Liane Lazoski
Brazil
Local time: 22:33
Native speaker of: Native in EnglishEnglish
PRO pts in category: 4

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Thiago Oliveira
2 hrs
Yes  Gustavo Vendrame
9 hrs
Yes  Beatriz Carretta
1 day 13 hrs
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