vitamin k-dependent plasma glycoprotein

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00:55 May 17, 2020
English to Japanese translations [PRO]
COVID-19 - Science - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical (general), Journalism
English term or phrase: vitamin k-dependent plasma glycoprotein
Definition from Science Direct:
Vitamin K–dependent proteins, synthesized in the liver, play a central role in blood coagulation through either procoagulant or anticoagulant mechanisms. The vitamin K–dependent protein family includes the zymogen procoagulant factors VII, IX, X, and prothrombin, and the anticoagulants protein C, protein S, and protein Z

Example sentence(s):
  • This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. National Center for Biotechnology Info.
  • Protein Z is a vitamin K-dependent glycoprotein isolated and characterized from human and bovine plasma. A cDNA coding for human protein Z has been obtained by the isolation of phage clones from a liver cDNA library and in vitro amplification of two other liver libraries. Research Gate
  • Four proteins active in blood coagulation have long been known to require vitamin K for their proper biosynthesis: factors II, VII, IX, and X. This paper describes the purification of a hitherto unrecognized vitamin K-dependent glycoprotein from bovine plasma. The biosynthesis of this protein is interfered with by the vitamin K antagonist Dicoumarol. The JBC
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GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
3 +1ビタミンK依存性糖タンパク質
Lurara


  

Translations offered


14 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
ビタミンK依存性糖タンパク質


Definition from own experience or research:
ビタミンK依存性タンパク質はGla殘基をもつタンパク質であり、糖タンパクとはたんぱく質に糖鎖が結合したものである。

Example sentence(s):
  •  プロテインS(PS)はビタミンK依存性糖タンパク質で、肝臓だけでなく血管内皮細胞や その他の細胞(Leydig細胞や骨髄巨核球など)も産生する。PS 遺伝子(PROS1)は第3染色体(3q11.2)に局在し全長110 kbで15個のエクソンを含むが、近傍(3p11.1)には偽遺伝子(PROSP)が存在する。 - 一般社団法人 日本血栓止血�  
Lurara
Japan
Local time: 14:36
Native speaker of: Japanese

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Mami Yamaguchi
37 days
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