vitamin k-dependent plasma glycoprotein

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00:54 May 17, 2020

English to Indonesian translations [PRO]
COVID-19 - Science - Medical (general)
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English term or phrase: vitamin k-dependent plasma glycoprotein

Definition from Science Direct:
Vitamin K–dependent proteins, synthesized in the liver, play a central role in blood coagulation through either procoagulant or anticoagulant mechanisms. The vitamin K–dependent protein family includes the zymogen procoagulant factors VII, IX, X, and prothrombin, and the anticoagulants protein C, protein S, and protein Z

Example sentence(s):

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. National Center for Biotechnology Info.
Protein Z is a vitamin K-dependent glycoprotein isolated and characterized from human and bovine plasma. A cDNA coding for human protein Z has been obtained by the isolation of phage clones from a liver cDNA library and in vitro amplification of two other liver libraries. Research Gate
Four proteins active in blood coagulation have long been known to require vitamin K for their proper biosynthesis: factors II, VII, IX, and X. This paper describes the purification of a hitherto unrecognized vitamin K-dependent glycoprotein from bovine plasma. The biosynthesis of this protein is interfered with by the vitamin K antagonist Dicoumarol. The JBC

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Summary of translations provided

Glikoprotein plasma yang bergantung kepada vitamin K

Siska Pradipta

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157 days confidence:

Glikoprotein plasma yang bergantung kepada vitamin K

Definition from own experience or research:
Glikoprotein plasma: Golongan protein yang berikatan dengan gula (oligosakarida) pada salah satu asam aminonya. Karena ia terdapat pada plasma darah maka dinamakan glikoprotein plasma.

Glikoprotein plasma yang bergantung kepada vitamin K: glikoprotein ini biasanya berperan dalam pembekuan darah. Ia membutuhkan vitamin K, entah dalam proses sintesis atau proses aktivasi, supaya dapat menjalankan fungsinya.

Example sentence(s):

Faktor II, VII, IX, dan X adalah protein plasma yang bergantung kepada vitamin K dalam menjalankan fungsinya sebagai faktor pembekuan darah. karena itu, kekurangan vitamin K dapat menyebabkan gangguan dalam pembekuan darah. - catatan kuliah

Siska Pradipta
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