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  3. Genetics

low BRCA1 along with high ERCC1 and/or XPG

German translation: niedrige BRCA1- und hohe ERCC1- und/oder XPG-Expression

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:low BRCA1 along with high ERCC1 and/or XPG
German translation:niedrige BRCA1- und hohe ERCC1- und/oder XPG-Expression
Entered by: Veronika Neuhold

20:44 Oct 18, 2010
English to German translations [PRO]
Medical - Genetics / oncology, sarcomas, chemotherapy, trabectedin
English term or phrase: low BRCA1 along with high ERCC1 and/or XPG
A retrospective study indicates that a composite signature based on DNA repair profile, **including low BRCA1 along with high ERCC1 and/or XPG**, identifies a highly sensitive population with highly improved treatment outcome. This signature could be used for patient’s enrichment studies in sarcoma and on other malignancies sensitive to trabectedin.
_ _ _

Ist hier eine "niedrige BRCA1- und hohe ERCC1-/XPG-Expression" gemeint?

"Eine retrospektive Studie weist darauf hin, dass mit einer ??? Signatur basierend auf einem DNA-Reparaturprofil **mit niedriger BRCA1- und hoher ERCC1-/XPG-Expression*** eine hoch sensitive Population identifiziert und dadurch das Therapieoutcome signifikant verbessert werden kann."

Vgl. http://haematologie-onkologie.universimed.com/artikel/dna-bl...
Veronika Neuhold
Austria
Local time: 00:03
niedrige BRCA1- und hohe ERCC1- u./o. XPG-Expression
Explanation:
Ja, ich würde hier auch "Expression" ergänzen.
Selected response from:

Anne Schulz
Germany
Local time: 00:03
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +3niedrige BRCA1- und hohe ERCC1- u./o. XPG-Expression
Anne Schulz


  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +3
low brca1 along with high ercc1 and/or xpg
niedrige BRCA1- und hohe ERCC1- u./o. XPG-Expression


Explanation:
Ja, ich würde hier auch "Expression" ergänzen.

Anne Schulz
Germany
Local time: 00:03
Works in field
Native speaker of: German
PRO pts in category: 32
Notes to answerer
Asker: Danke!


Peer comments on this answer (and responses from the answerer)
agree  Dr. Anja Masselli
13 hrs
  -> Danke Anja!
agree  MMUlr
14 hrs
  -> Danke Margret!
agree  Harald Moelzer (medical-translator)
1 day 16 hrs
  -> Danke Harald!
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