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composite signature

German translation: eine aus einer Kombination der Expressionsprofile mehrerer DNA-Reparaturgene abgeleitete Signatur

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:a composite signature based on DNA repair profile
German translation:eine aus einer Kombination der Expressionsprofile mehrerer DNA-Reparaturgene abgeleitete Signatur
Entered by: Veronika Neuhold

20:38 Oct 18, 2010
English to German translations [PRO]
Medical - Genetics / oncology, sarcomas, chemotherapy, trabectedin
English term or phrase: composite signature
A retrospective study indicates that a **composite signature** based on DNA repair profile, including low BRCA1 along with high ERCC1 and/or XPG, identifies a highly sensitive population with highly improved treatment outcome. This signature could be used for patient’s enrichment studies in sarcoma and on other malignancies sensitive to trabectedin.
_ _ _

Zusammengsetzte Signatur?
Gemischte Signatur?
Kombinationssignatur?

Vielen Dank im Voraus!
Veronika Neuhold
Austria
Local time: 22:37
Kombinationssignatur
Explanation:
Ich wäre für "Kombination" (aber "zusammengesetzt" geht wohl auch).
Vielleicht in etwas anderer "Kombination": ...dass eine aus einer Kombination von DNA-Reparaturenzymen abgeleitete Signatur - mit niedriger BRCA1-, aber hoher ERCC!- und/oder XPG-Expression - eine hochsensible Population charakterisiert, für die ein wesentlich verbessertes Therapieergebnis erzielt werden kann.
Selected response from:

Anne Schulz
Germany
Local time: 22:37
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +1Kombinationssignatur
Anne Schulz


  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
Kombinationssignatur


Explanation:
Ich wäre für "Kombination" (aber "zusammengesetzt" geht wohl auch).
Vielleicht in etwas anderer "Kombination": ...dass eine aus einer Kombination von DNA-Reparaturenzymen abgeleitete Signatur - mit niedriger BRCA1-, aber hoher ERCC!- und/oder XPG-Expression - eine hochsensible Population charakterisiert, für die ein wesentlich verbessertes Therapieergebnis erzielt werden kann.

Anne Schulz
Germany
Local time: 22:37
Works in field
Native speaker of: German
PRO pts in category: 32
Notes to answerer
Asker: Vielen Dank!


Peer comments on this answer (and responses from the answerer)
agree  Dr. Anja Masselli: mit der Neuformulierung. Noch genauer: aus einer Kombination der Expressionsprofile mehrerer DNA-Reparaturgene/-enzyme
13 hrs
  -> Noch besser - danke, Anja!
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