loss of function allele

00:13 Oct 17, 2010
This question was closed without grading. Reason: Answer found elsewhere

English to German translations [PRO]
Medical - Genetics
English term or phrase: loss of function allele
Approximately 27 percent of subjects were categorized as reduced-metabolizers of CYP2C19 (with at least one loss of function allele).
Julia Cornelius
Germany
Local time: 11:45


Summary of answers provided
3 +3Verlust des funktionellen Allel
swisstell
3 +2nichtfunktionales/nichtfunktionelles Allel
Anne Schulz
1 +2Verlust der Allelfunktion
andres-larsen


  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +3
Verlust des funktionellen Allel


Explanation:
www.springerlink.com/index/I038648717q72983.pdf

swisstell
Italy
Local time: 11:45
Native speaker of: German

Peer comments on this answer (and responses from the answerer)
agree  Anne Schulz: Verlust mindestens eines funktionellen Allels
1 day 3 hrs
  -> thanks, and yes, yous is better!

agree  Harald Moelzer (medical-translator): mit Anne
1 day 5 hrs
  -> danke, Harald.

agree  Dr. Anja Masselli: mit Anne und Harald
1 day 9 hrs
  -> danke, ich auch .....
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1 hr   confidence: Answerer confidence 1/5Answerer confidence 1/5 peer agreement (net): +2
Verlust der Allelfunktion


Explanation:
Verlust der Allelfunktion

Quellen:

[PDF] Stroke News, 01-2007 - : PDF/Adobe Acrobat - Quick view
Träger der reduzierten ***Allelfunktion von CYP2C19*** hatten eine 53%ige relative Risikoerhöhung für den primären Endpunkt vaskulärer Tod, ...
www.stroke-news.de/pdf/Stroke_News_01_09.pdf

W.-E. Loennig: Gesetz der rekurrenten Variation - Mikroevolution durch Degeneration (***Verlust von Genfunktionen und ... Und das ist auch von den Allelfunktionen*** her zu erwarten: "…we see in multiple alleles, ...
www.weloennig.de/Gesetz_Rekurrente_Variation.html -

andres-larsen
Venezuela
Local time: 06:45
Native speaker of: Native in EnglishEnglish

Peer comments on this answer (and responses from the answerer)
agree  Dr. rer. nat. Annett Behn-Krappa: Loss-of-function bezeichnet eine bestimmte Klasse von Mutationen (http://de.wikipedia.org/wiki/Loss-of-function-Mutation)
4 hrs

agree  MMUlr: mit Annett - Näheres hier: http://www.deutsche-apotheker-zeitung.de/pharmazie/news/2010...
8 hrs
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1 day 5 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
nichtfunktionales/nichtfunktionelles Allel


Explanation:
"loss of function" gehört zusammen als Quasi-Adjektiv (wie von den Kollegen bereits bemerkt)

Anne Schulz
Germany
Local time: 11:45
Works in field
Native speaker of: German
PRO pts in category: 32

Peer comments on this answer (and responses from the answerer)
agree  Harald Moelzer (medical-translator): gute Lösung :-)
1 hr
  -> Danke Harald!

agree  Dr. Anja Masselli
5 hrs
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