hit
French translation: hits/les premières molécules identifiées
| GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||||
|---|---|---|---|---|---|---|
|
| 14:58 Mar 8, 2021 |
| English to French translations [PRO] Medical - Medical: Health Care / virology | |||||||
|---|---|---|---|---|---|---|---|
|
| ||||||
|  Selected response from: liz askew United Kingdom Local time: 07:30 | ||||||
Grading comment
| |||||||
| Summary of answers provided | ||||
|---|---|---|---|---|
| 4 | molécules |
| ||
| 4 | hits/les premières molécules identifiées |
|
| Discussion entries: 6 | |
|---|---|
Answers
6 mins confidence: 
molécules Explanation: https://pubmed.ncbi.nlm.nih.gov/33497607/ Abstract The spread of the corona virus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been intensifying in the past year, posing a huge threat to global health. There is an urgent need for effective drugs and vaccines to fight the COVID-19, but their advent may not be quite fast. Drug repurposing is a feasible strategy in the current situation, which could greatly shorten drug development time and help to response quickly to the novel virus outbreak. It has been reported that histamine H1 receptor antagonists have broad-spectrum antiviral effects. Therefore, in this study, we aim to screen potential drugs among histamine H1 receptor antagonists that may inhibit SARS-CoV-2 infection. Based on the model of angiotensin-converting enzyme 2 (ACE2) overexpressing HEK293T cell membrane chromatography (CMC), five FDA-approved histamine H1 receptor antagonists were found to have bioaffinity to ACE2. Then we determined the interaction between these drugs and ACE2 by frontal analysis and surface plasmon resonance (SPR), which consistently demonstrated that these hits bind to ACE2 at micromolar levels of affinity. Through the pseudovirus assay, we finally identified that doxepin could inhibit SARS-CoV-2 spike pseudovirus from entering the ACE2-expressing cell, reducing the infection rate to 25.82%. These preliminary results indicate that the histamine H1 receptor antagonist, doxepin, is a viable drug candidate for clinical trials. Therefore, we hope the work timely provides rational help for developing anti-SARS-CoV-2 drugs to control the rapid spread of SARS-CoV-2. |
| |
| Login to enter a peer comment (or grade) | ||
33 mins confidence:
hits/les premières molécules identifiées Explanation: Conception d'un logiciel de docking et applications ... - DUMASdumas.ccsd.cnrs.fr › dumas-01115990 › document 12 Feb 2015 — Immunologie / Microbiologie / Biotechnologie ... Virologie (I.B.S.) ... proches des premières molécules identifiées (les « hits ») avec l'activité désirée [114]. Les ... inhibitor leads., J Comput Aided Mol Des, 1992, 6 : 593-606. |
| ||
Grading comment
| |||
Notes to answerer
| |||
| Login to enter a peer comment (or grade) | |||
Login or register (free and only takes a few minutes) to participate in this question.
You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.
KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.
See also:
Search millions of term translations