recombinant antibody

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00:55 Sep 14, 2020

English to Chinese translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Medical: Pharmaceuticals, Medical (general)

English term or phrase: recombinant antibody

Definition from Pharma IQ:
A Recombinant Antibody is defined as an antibody produced by genetic engineering. Recombinant antibody has significant advantages compared with the conventional antibody and there for its use becoming more popular now days. The fact that no animals are needed in the manufacturing procedure of the recombinant antibodies, in addition, the manufacturing time is relatively short compared with the conventional method. Moreover, the quality of the final product is higher that these of the non recombinant method.

Example sentence(s):

By the recombinant DNA technology, link purified genes of VH and VL with prokaryotic expression vector which requires select in advance based on your target recombinant antibody fragments. If you need scfv fragment antibody, linker must be designed in your PCR strategy. Creative Biolabs
One of the first recombinant antibody fusions with therapeutic potential consisted of a monoclonal antibody, specific for the fibrin β-chain, in which the Fc portion was replaced with an engineered version of the β-chain of tissue-type plasminogen activator (t-PA) (144). Science Direct
Also delivering custom recombinant antibody production, GenScript has invested many years in optimizing its cell lines, gene synthesis and plasmid preparation, transfection reagents, and media systems to offer a suite of different services. Biocompare

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重组抗体

Frank Feng

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重组抗体

Definition from Cell Signaling Technology:
什么是重组抗体？
传统的多克隆和单克隆抗体是正常 B 细胞发育和基因重组的产物。它们是通过用抗原免疫动物以引发免疫应答而产生的。多克隆抗体由许多不同的 B 细胞克隆分泌并识别多个抗原表位，而单克隆抗体则来自单个 B 细胞克隆，并且仅对一个表位具有特异性。

重组抗体是单克隆抗体，但是其生产涉及体外遗传操纵。将抗体基因克隆到表达载体中后，将其转染到合适的宿主细胞系中进行抗体表达。哺乳动物细胞系最常用于重组抗体的生产，尽管细菌、酵母或昆虫来源的细胞系也适用。

Example sentence(s):

重组抗体药物的发展经历了鼠源单克隆抗体（ＭｃＡｂ）、人鼠嵌合抗体、人源化抗体和全人抗体等阶段，目前初步应用于抗肿瘤、抗自身免疫病、抗感染等领域。保持和提高抗体的亲和力、降低抗体的免疫原性是抗体药物基因工程改造的两大原则。在嵌合抗体成功的基础上，通过ＣＤＲ移植、表面修饰、抗体库以及转基因鼠技术，逐步提高人源化程度至１００％。然而，实验室水平的研究结果与实际应用仍然存在一定差距。就重组抗体药物的基本概况、现存的问题与可能的解决办法以及在肿瘤、病毒性疾病和阿尔茨海默病治疗上的应用情况等进行了综述。 - China Biotechnology
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法所不可能做到的。 - 《重组抗体》——科学出版社

Frank Feng
China
Local time: 18:37
Native speaker of: Chinese
PRO pts in category: 4

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