Anti-adhesion molecule therapy
Bulgarian translation: терапия с инхибитори на адхезионните молекули
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| 17:38 Jan 7, 2013 |
| English to Bulgarian translations [PRO] Medical - Medical: Pharmaceuticals / clinical trial | |||||
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|  Selected response from: Ekaterina Kroumova | ||||
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| anti-adhesion molecule therapy антиадхезионна молекулярна терапия Explanation: Терапия с антиадхезионни молекули Reference: http://www.invitro.bg/images/stories/pdf/Embryology_3.pdf |
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peer agreement (net): +1| anti-adhesion molecule therapy терапия с инхибитори на адхезивните молекули Explanation: или терапия за инхибиране на адхезивните молекули Според мене тук "anti" има смисъла на възпрепятстване на адхезивните молекули, а не че молекулите са антиадхезивни. За адхезивните молекули вж тук: http://bg.wikipedia.org/wiki/Клетъчна_адхезия Адхезивните молекули изглежда са виновни за някои автоимунни и възпалителни заболявания, като се "престарават": Adhesion molecules regulate the influx of leukocytes in normal and inflamed gut. Some of these molecules such as MadCAM-1 are specific for the gastrointestinal endothelium, but in inflammatory bowel diseases most of the adhesion factors are up-regulated. Adhesion molecules also are involved in local lymphocyte stimulation and antigen presentation within the intestinal mucosa. Recently, therapeutic compounds directed against trafficking of lymphocytes toward the gut mucosa have been designed, and are being developed as a novel class of drugs in the treatment of Crohn's disease (CD) and ulcerative colitis. This review deals with the immunological aspects of leukocyte trafficking focused on gut homing of T cells. Secondly, the changes in adhesion molecules and T-cell trafficking during intestinal inflammation are discussed. Finally, we review the clinical data that have been gathered in trials of biological therapies directed against adhesion molecules. http://www.ncbi.nlm.nih.gov/pubmed/12131614 Такъв инхибитор на адхезивни молекули е Натализумаб: http://www.ema.europa.eu/docs/bg_BG/document_library/EPAR_-_... -------------------------------------------------- Note added at 3 часа (2013-01-07 21:04:38 GMT) -------------------------------------------------- Всъщност, тези инхибитори са въпросните антиадхезивни молекули и в този смисъл отговорът на колегата Гулев е правилен в постановката "терапия с антиадхезионни (или антиадхезивни) молекули": http://ajpgi.physiology.org/content/288/2/G169.full http://ajpgi.physiology.org/content/288/2/G169/T2.expansion.... -------------------------------------------------- Note added at 3 часа (2013-01-07 21:08:21 GMT) -------------------------------------------------- http://www.ingentaconnect.com/content/ben/cdd/2012/00000009/... |
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