Glossary entry (derived from question below)
English term or phrase:
pharmacological augmentation
French translation:
l\'ajout d\'une seconde molécule/d’un second antidépresseur
Added to glossary by
liz askew
Jul 23, 2019 11:38
4 yrs ago
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English term
United Kingdom
Medical translator and proofreader
Native in: French (Variant: Standard-France) 
Works in: English to French
pharmacological augmentation
English to French
Medical
Medical: Pharmaceuticals
psychiatrie
Compare and contrast the strategies of oral antidepressant switching and pharmacological augmentation in patients with MDD who are intolerant to and/or have only a partial response to first-line SSRI treatment
Proposed translations
(French)
| 4 +3 | l'ajout d'une seconde molécule |
liz askew
|
| 4 +1 | augmentation du nombre d'agents pharmacologiques utilisés |
FX Fraipont (X)
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Change log
Jul 25, 2019 15:47: liz askew changed "Edited KOG entry" from "<a href="/profile/1580284">Bertrand Leduc's</a> old entry - "pharmacological augmentation"" to ""l\'ajout d\'une seconde molécule/d’un second antidépresseur""
Proposed translations
+3
24 mins
Selected
l'ajout d'une seconde molécule
Patients hospitalisés au Centre Hospitalier du ... - Semantic Scholar
https://pdfs.semanticscholar.org/.../79b7bbb515ebc440b797843...
Translate this page
24 Nov 2017 - dépressif majeur : modification du traitement antidépresseur entre l'entrée ...... L'ajout d'une seconde molécule ne peut être entrepris qu'après ...
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Note added at 26 mins (2019-07-23 12:04:48 GMT)
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Augmentation, in the context of the pharmacological management of psychiatry, refers to the combination of two or more drugs to achieve better treatment results. Examples include:
Prescribing an atypical antipsychotic when someone is already taking a selective serotonin reuptake inhibitor for the treatment of depression.[1]
Prescribing estrogen for someone already being treated with antipsychotics for the management of schizophrenia.[2]
Giving an adenosine A2A receptor antagonist on top of existing treatment for Parkinson's disease.[3]
https://pdfs.semanticscholar.org/.../79b7bbb515ebc440b797843...
Translate this page
24 Nov 2017 - dépressif majeur : modification du traitement antidépresseur entre l'entrée ...... L'ajout d'une seconde molécule ne peut être entrepris qu'après ...
--------------------------------------------------
Note added at 26 mins (2019-07-23 12:04:48 GMT)
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Augmentation, in the context of the pharmacological management of psychiatry, refers to the combination of two or more drugs to achieve better treatment results. Examples include:
Prescribing an atypical antipsychotic when someone is already taking a selective serotonin reuptake inhibitor for the treatment of depression.[1]
Prescribing estrogen for someone already being treated with antipsychotics for the management of schizophrenia.[2]
Giving an adenosine A2A receptor antagonist on top of existing treatment for Parkinson's disease.[3]
Note from asker:
| Merci, Liz ! |
4 KudoZ points awarded for this answer.
+1
11 mins
augmentation du nombre d'agents pharmacologiques utilisés
AKA polypharmacy, association of different antidepressors
"Due to these considerations, antidepressant polypharmacy is only recommended for patients with treatmentresistant depression who may benefit from the synergistic effect of employing medications that have different mechanisms of action. This rationale based on pharmacological augmentation is highlighted in the recommendations of the American Psychiatry Association’s Practice guideline for the treatment of patients with major depressive disorder. [4]
...
In clinical practice, psychiatrists usually start with one antidepressant. If there is no benefit or the side effects are severe the clinician will change the treatment to another antidepressant. If there is partial benefit and the side effects are relatively mild there are three potential options: (a) increase the dose of the first medication; (b) change to another medication; or (c) augment the first medication with a second antidepressant with an alternative mechanism of action that should, theoretically, improve the treatment effect without seriously exacerbating the side effects."
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Note added at 11 mins (2019-07-23 11:49:59 GMT)
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311109/
"Due to these considerations, antidepressant polypharmacy is only recommended for patients with treatmentresistant depression who may benefit from the synergistic effect of employing medications that have different mechanisms of action. This rationale based on pharmacological augmentation is highlighted in the recommendations of the American Psychiatry Association’s Practice guideline for the treatment of patients with major depressive disorder. [4]
...
In clinical practice, psychiatrists usually start with one antidepressant. If there is no benefit or the side effects are severe the clinician will change the treatment to another antidepressant. If there is partial benefit and the side effects are relatively mild there are three potential options: (a) increase the dose of the first medication; (b) change to another medication; or (c) augment the first medication with a second antidepressant with an alternative mechanism of action that should, theoretically, improve the treatment effect without seriously exacerbating the side effects."
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Note added at 11 mins (2019-07-23 11:49:59 GMT)
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311109/
Note from asker:
| Merci ! |
Reference comments
15 mins
Reference:
see
https://www.mayoclinic.org/diseases-conditions/depression/in...
Add a medication generally used for another condition. Your doctor may prescribe a medication that's generally used for another mental or physical health problem, along with an antidepressant. This approach, known as augmentation, may include antipsychotics, mood stabilizers, anti-anxiety medications, thyroid hormone or other drugs.
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Note added at 19 mins (2019-07-23 11:58:03 GMT)
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https://tel.archives-ouvertes.fr/tel-00663312/document
by TH Nguyen - 2011 - Cited by 1 - Related articles
26 Jan 2012 - qu'un traitement prolongé avec un ISRS, augmente la densité des ...... La seconde repose sur *** l'ajout d'une seconde molécule*** (stratégie.
Add a medication generally used for another condition. Your doctor may prescribe a medication that's generally used for another mental or physical health problem, along with an antidepressant. This approach, known as augmentation, may include antipsychotics, mood stabilizers, anti-anxiety medications, thyroid hormone or other drugs.
--------------------------------------------------
Note added at 19 mins (2019-07-23 11:58:03 GMT)
--------------------------------------------------
https://tel.archives-ouvertes.fr/tel-00663312/document
by TH Nguyen - 2011 - Cited by 1 - Related articles
26 Jan 2012 - qu'un traitement prolongé avec un ISRS, augmente la densité des ...... La seconde repose sur *** l'ajout d'une seconde molécule*** (stratégie.
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